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Hepatic impairment: Start out conservatively having a lessen than common dose; titrate cautiously to sought after result.CYP450 3A4 Interaction: The concomitant use with CYP450 3A4 inhibitors (or discontinuation of CYP450 3A4 inducers) could cause a lethal overdose of oxycodone.This medication comes with a Medication Guide and affected individual G